Effects of Recombinant Human Erythropoietin on Inflammatory Factors in Rats with Traumatic Brain Injury

To study the effects of recombinant human erythropoietin on inflammatory factors in rats with traumatic brain injury is main objective. A total 45 specific-pathogen-free grade male Sprague-Dawley were randomly assigned into sham operation group (sham group), model and intervention (treatment group) (n=15). Model treatment groups prepared by hitting head through modified Feeney’s free-fall impact method, while was not hit. After modeling, intraperitoneally injected at 5000 IU/kg daily same dose normal saline. The killed after 7 d continuous administration. changes mitochondrial membrane potential detected rhodamine 123 staining immunocytochemistry Western blotting separately employed to measure expressions interleukin-1β, interleukin-6 tumor necrosis factor-α tissues expression levels dynamin-related protein 1, fission mitofusin 2 optic atrophy dynamics related proteins tissues. Compared group, exhibited significantly weakened fluorescence intensity, increased factor-α, 1 reduced (p<0.05). In comparison had enhanced elevated Recombinant can protect relieving response injury.